That's an issue too!

Almost everyone here in the Netherlands rides sitting upright. I have had wrist issues from RSI but sitting upright, all my weight is on my butt, none on my wrists.

I'll never go back to a bike where I lean over again. I'm getting on, and I assume my lower back would also hate this.

(I won't go back to a derailleur again either, now I've experienced the marvels of having sealed gears in your rear hub, thanks Shimano! But that's another story...)